Atherton G W, James N T
Virchows Arch B Cell Pathol Incl Mol Pathol. 1985;50(1):91-9. doi: 10.1007/BF02889893.
Stereological analyses of the pattern of distribution of heterochromatin and euchromatin in nuclei of muscle fibres are reported. Patterns of distribution found in myonuclei from extensor digitorum longus muscle of C57BL/6Jdy2J/dy2J dystrophic mice were compared with those found in myonuclei from the same muscle of clinically unaffected littermates and of normal control mice. Using a well-known spatial pattern analysis technique, clear differences between these types of nuclei were found. Such differences are clearly of value in helping our understanding of the pathological processes occurring in dystrophic muscle, and may be relevant to future identification and diagnosis of abnormal muscle.
本文报道了对肌纤维细胞核中异染色质和常染色质分布模式的体视学分析。将C57BL/6Jdy2J/dy2J营养不良小鼠的趾长伸肌肌细胞核中的分布模式，与临床未受影响的同窝小鼠和正常对照小鼠同一肌肉的肌细胞核中的分布模式进行了比较。使用一种著名的空间模式分析技术，发现了这些类型细胞核之间的明显差异。这些差异对于帮助我们理解营养不良肌肉中发生的病理过程显然具有重要价值，并且可能与未来异常肌肉的识别和诊断有关。
