Atherton G W, Cabric M, James N T
Virchows Arch A Pathol Anat Histol. 1982;397(3):347-54. doi: 10.1007/BF00496575.
Stereological analyses of the distribution of capillaries in skeletal muscles of congenitally dystrophic mice are described and reported. Two methods are used, each based on a different mathematical model of the 3-dimensional distribution of lines in space. For these analyses specimens of extensor digitorum longus muscle from clinically affected C57BL/6Jdy2J/dy2J dystrophic mice, and from non-littermate controls, were used. The analyses were carried out on transverse and longitudinally orientated semithin sections of these muscles. Although the two methods employed are based on different mathematical models and yield results relevant to each particular model, it is clear that there is a more extensive capillary network present per unit volume of the dystrophic muscle than in control muscles. These findings are relevant to the theories which involve a vascular aetiology for muscular dystrophy. It is apparent that, in order to explore the structure of the capillary network more fully, there is a need for the development of more sophisticated stereological techniques for analysis of capillaries in skeletal muscle.
本文描述并报告了对先天性营养不良小鼠骨骼肌中毛细血管分布的体视学分析。使用了两种方法，每种方法基于空间中线的三维分布的不同数学模型。为了进行这些分析，使用了来自临床受影响的C57BL/6Jdy2J/dy2J营养不良小鼠以及非同窝对照的趾长伸肌标本。对这些肌肉的横向和纵向半薄切片进行了分析。尽管所采用的两种方法基于不同的数学模型并产生与每个特定模型相关的结果，但很明显，与对照肌肉相比，营养不良肌肉的每单位体积中存在更广泛的毛细血管网络。这些发现与涉及肌肉营养不良血管病因的理论相关。显然，为了更全面地探索毛细血管网络的结构，需要开发更复杂的体视学技术来分析骨骼肌中的毛细血管。
