Anson Eric, Bigelow Robin T, Swenor Bonnielin, Deshpande Nandini, Studenski Stephanie, Jeka John J, Agrawal Yuri
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of MedicineBaltimore, MD, United States.
Lions Vision Center, Wilmer Eye Institute, Johns Hopkins University School of MedicineBaltimore, MD, United States.
Front Aging Neurosci. 2017 Jun 20;9:202. doi: 10.3389/fnagi.2017.00202. eCollection 2017.
Postural sway increases with age and peripheral sensory disease. Whether, peripheral sensory function is related to postural sway independent of age in healthy adults is unclear. Here, we investigated the relationship between tests of visual function (VISFIELD), vestibular function (CANAL or OTOLITH), proprioceptive function (PROP), and age, with center of mass sway area (COM) measured with eyes open then closed on firm and then a foam surface. A cross-sectional sample of 366 community dwelling healthy adults from the Baltimore Longitudinal Study of Aging was tested. Multiple linear regressions examined the association between COM and VISFIELD, PROP, CANAL, and OTOLITH separately and in multi-sensory models controlling for age and gender. PROP dominated sensory prediction of sway across most balance conditions (β's = 0.09-0.19, 's < 0.001), except on foam eyes closed where CANAL function loss was the only significant sensory predictor of sway (β = 2.12, < 0.016). Age was not a consistent predictor of sway. This suggests loss of peripheral sensory function explains much of the age-associated increase in sway.
姿势晃动会随着年龄增长和周围感觉系统疾病而增加。在健康成年人中，周围感觉功能是否独立于年龄与姿势晃动相关尚不清楚。在此，我们研究了视觉功能测试（VISFIELD）、前庭功能测试（CANAL或OTOLITH）、本体感觉功能测试（PROP）与年龄之间的关系，并在睁眼和闭眼状态下，分别在坚实表面和泡沫表面测量了重心晃动面积（COM）。我们对来自巴尔的摩纵向衰老研究的366名社区居住健康成年人进行了横断面抽样测试。多元线性回归分别以及在控制年龄和性别的多感觉模型中，检验了COM与VISFIELD、PROP、CANAL和OTOLITH之间的关联。在大多数平衡条件下，PROP在感觉预测晃动方面占主导地位（β值=0.09 - 0.19，P值<0.001），但在闭眼站在泡沫表面时，CANAL功能丧失是晃动的唯一显著感觉预测因素（β = 2.12，P < 0.016）。年龄并非晃动的一致预测因素。这表明周围感觉功能丧失解释了与年龄相关的晃动增加的大部分原因。
