Tkaczyk Eric
One Hundred Oaks Suite 26300, 719 Thompson Lane, TN 37204 Nashville, USA.
Acta Derm Venereol. 2017;Suppl 218:5-13. doi: 10.2340/00015555-2717. Epub 2017 Jul 5.
Most dermatologists are aware of the benefits of dermoscopy, and a few are familiar with laser-scanning confocal microscopy. Beyond confocal, there are fully 11 different categories of optical techniques that have been applied to clinical dermatology. This article first provides a comprehensive tabular overview of all these optical diagnostic technologies and then details 4 of the lesser known innovations that are already available or still in development (laser Doppler and speckle imaging, Raman spectroscopy, multiphoton microscopy, photoacoustic tomography), with some potential applications in clinical dermatology (blood flow monitoring, skin cancer diagnosis, composition measurements in atopic dermatitis, skin rejuvenation measurement, and noninvasive sentinel lymph node assessment in melanoma). These methods present many advantages, being non-invasive, portable, and rapid. The development of optics in biological and biomedical sciences (i.e. biophotonics) requires not only deep insight into the applications but also synergistic collaboration be-tween engineers and clinicians.
大多数皮肤科医生都了解皮肤镜检查的益处，少数人熟悉激光扫描共聚焦显微镜检查。除了共聚焦技术外，还有足足11种不同类别的光学技术已应用于临床皮肤科。本文首先全面以表格形式概述所有这些光学诊断技术，然后详细介绍4种鲜为人知但已可用或仍在研发中的创新技术（激光多普勒和散斑成像、拉曼光谱、多光子显微镜、光声断层扫描），以及它们在临床皮肤科的一些潜在应用（血流监测、皮肤癌诊断、特应性皮炎的成分测量、皮肤年轻化测量以及黑色素瘤的无创前哨淋巴结评估）。这些方法具有许多优点，如无创、便携且快速。生物和生物医学科学中的光学发展（即生物光子学）不仅需要深入了解其应用，还需要工程师和临床医生之间的协同合作。
