Koyama Kazuya, Mitsumoto Takuya, Shiraishi Takahiro, Tsuda Keisuke, Nishiyama Atsushi, Inoue Kazumasa, Yoshikawa Kyosan, Hatano Kazuo, Kubota Kazuo, Fukushi Masahiro
Japan Health Care College, Hokkaido, Japan.
Graduate School of Human Health Sciences, Tokyo Metropolitan University, 7-2-10, Higashiogu, Arakawa-ku, Tokyo, 116-8551, Japan.
Radiol Phys Technol. 2017 Sep;10(3):311-320. doi: 10.1007/s12194-017-0405-6. Epub 2017 Jul 4.
We aimed to determine the difference in tumor volume associated with the reconstruction model in positron-emission tomography (PET). To reduce the influence of the reconstruction model, we suggested a method to measure the tumor volume using the relative threshold method with a fixed threshold based on peak standardized uptake value (SUV). The efficacy of our method was verified using F-2-fluoro-2-deoxy-D-glucose PET/computed tomography images of 20 patients with lung cancer. The tumor volume was determined using the relative threshold method with a fixed threshold based on the SUV. The PET data were reconstructed using the ordered-subset expectation maximization (OSEM) model, the OSEM + time-of-flight (TOF) model, and the OSEM + TOF + point-spread function (PSF) model. The volume differences associated with the reconstruction algorithm (%VD) were compared. For comparison, the tumor volume was measured using the relative threshold method based on the maximum SUV (SUV). For the OSEM and TOF models, the mean %VD values were -0.06 ± 8.07 and -2.04 ± 4.23% for the fixed 40% threshold according to the SUV and the SUV respectively. The effect of our method in this case seemed to be minor. For the OSEM and PSF models, the mean %VD values were -20.41 ± 14.47 and -13.87 ± 6.59% for the fixed 40% threshold according to the SUV and SUV, respectively. Our new method enabled the measurement of tumor volume with a fixed threshold and reduced the influence of the changes in tumor volume associated with the reconstruction model.
我们旨在确定正电子发射断层扫描（PET）中与重建模型相关的肿瘤体积差异。为减少重建模型的影响，我们提出了一种基于峰值标准化摄取值（SUV）使用固定阈值的相对阈值法来测量肿瘤体积的方法。我们使用20例肺癌患者的F-2-氟-2-脱氧-D-葡萄糖PET/计算机断层扫描图像验证了该方法的有效性。使用基于SUV的固定阈值的相对阈值法确定肿瘤体积。PET数据使用有序子集期望最大化（OSEM）模型、OSEM + 飞行时间（TOF）模型和OSEM + TOF + 点扩散函数（PSF）模型进行重建。比较了与重建算法相关的体积差异（%VD）。为作比较，基于最大SUV（SUV）使用相对阈值法测量肿瘤体积。对于OSEM和TOF模型，根据SUV和SUV，固定40%阈值时的平均%VD值分别为-0.06 ± 8.07和-2.04 ± 4.23%。在这种情况下，我们方法的效果似乎较小。对于OSEM和PSF模型，根据SUV和SUV，固定40%阈值时的平均%VD值分别为-20.41 ± 14.47和-13.87 ± 6.59%。我们的新方法能够使用固定阈值测量肿瘤体积，并减少了与重建模型相关的肿瘤体积变化的影响。
