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[双侧嗜铬细胞瘤及疑似多发性内分泌肿瘤的麻醉学特点]

[Anesthesiologic peculiarities in bilateral pheochromocytoma and suspected multiple endocrine neoplasia].

作者信息

Hack G, Mihanovic N, Helpap B

出版信息

Anasth Intensivther Notfallmed. 1985 Oct;20(5):269-72.

PMID:2867711
Abstract

Based on a case report with surgical removal of bilateral giant phaeochromocytomas with heredofamilial affliction and suspicion of multiple endocrine neoplasia type II (MEN-II syndrome) and of malignancy, the anaesthetic implications are discussed in a patient inadvertently not prepared by antiadrenergic treatment. It is pointed out that in MEN II syndrome, a combination of phaeochromocytoma and medullary carcinoma of the thyroid, surgical removal of the phaeochromocytoma merits utmost priority before thyreoidectomy. The most important laboratory parameters in the diagnosis of MEN II syndrome are pre- and postoperative determinations of calcitonin and carcinoembryonal antigen (CEA).

摘要

基于一例双侧巨大嗜铬细胞瘤手术切除病例报告,该病例存在遗传家族性疾病,怀疑为II型多发性内分泌肿瘤(MEN-II综合征)且有恶变可能,本文讨论了在未进行抗肾上腺素能治疗准备的情况下该患者的麻醉相关问题。文中指出,在MEN II综合征中,嗜铬细胞瘤与甲状腺髓样癌并存时,在甲状腺切除术之前,优先切除嗜铬细胞瘤至关重要。诊断MEN II综合征最重要的实验室指标是术前和术后降钙素及癌胚抗原(CEA)的测定。

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