IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
Asociación Civil IMPACTA Salud y Educacion, Lima, Peru.
HLA. 2017 Oct;90(4):234-237. doi: 10.1111/tan.13085. Epub 2017 Jul 5.
Associations between HLA class II polymorphisms and HIV control were assessed in a Peruvian MSM cohort. Among 233 treatment naïve HIV+ individuals, DRB113:02 was linked to elevated viral loads (P = .044) while DRB112:01 showed significantly lower viral set points (P = .015) and restricted a dominant T cell response to HIV Gag p24 (P = .038). The present work contributes to a better knowledge of the Peruvian immunogenetics and supports the important role of HLA class II restricted T cells in HIV control.
在秘鲁男男性行为者队列中，评估了 HLA Ⅱ类基因多态性与 HIV 控制之间的关联。在 233 名未经治疗的 HIV 阳性个体中，DRB113:02 与较高的病毒载量相关（P =.044），而 DRB112:01 则显示出显著较低的病毒起始点（P =.015），并限制了对 HIV Gag p24 的主导性 T 细胞反应（P =.038）。本研究有助于更好地了解秘鲁的免疫遗传学，并支持 HLA Ⅱ类限制的 T 细胞在 HIV 控制中的重要作用。
