Schwarz S, Agoston S, Houwertjes M C
Anesth Analg. 1986 Feb;65(2):156-60.
The dose requirement for 95% depression of twitch tension and the time course of the neuromuscular blocking effects of the ED95 of pancuronium bromide and vecuronium bromide were studied during intravenous infusion of glucose, 5%, and nitroglycerin, 1 microgram X kg-1 X min-1, in 20 cats anesthetized with pentobarbital. Nitroglycerin administered continuously starting 1 hr before the administration of the ED95 and maintained during at least five maintenance doses of either pancuronium or vecuronium did not significantly potentiate the action of the neuromuscular blocking drugs, nor did it alter their time course of action. A tendency for a decrease (statistically not significant) rather than an increase in the duration of action of maintenance doses of both pancuronium and vecuronium was apparent during the treatment with nitroglycerin. These findings indicate a lack of interaction between pancuronium or vecuronium and nitroglycerin, provided that moderate doses are used.
在20只戊巴比妥麻醉的猫中，研究了静脉输注5%葡萄糖和1微克/千克/分钟硝酸甘油期间，泮库溴铵和维库溴铵ED95产生95%颤搐张力抑制的剂量需求及其神经肌肉阻滞作用的时间过程。在给予ED95前1小时开始持续给予硝酸甘油，并在至少五个泮库溴铵或维库溴铵维持剂量期间持续给药，结果显示硝酸甘油并未显著增强神经肌肉阻滞药物的作用，也未改变其作用的时间过程。在硝酸甘油治疗期间，泮库溴铵和维库溴铵维持剂量的作用持续时间有缩短趋势（统计学上无显著意义）而非延长。这些发现表明，使用中等剂量时，泮库溴铵或维库溴铵与硝酸甘油之间不存在相互作用。
