Sohn Y J, Bencini A F, Scaf A H, Kersten U W, Agoston S
Anesth Analg. 1986 Mar;65(3):233-9.
Plasma concentrations and the degree of neuromuscular blockade after a 2-min infusion of 0.1 mg/kg of vecuronium bromide or pancuronium bromide (equipotent doses) were studied in 12 gynecologic patients. The plasma concentrations of both drugs declined in a triphasic manner. The difference between the intercepts and rate constants of the two drugs was not significant. Vecuronium was removed faster from the plasma than pancuronium; this was reflected in a significantly larger plasma clearance rate for vecuronium (4 ml X min-1 X kg-1 vs 1.1 ml X min-1 X kg-1 for pancuronium). The effective plasma concentrations at 50% recovery of the twitch height were 0.11 +/- 0.02 (vecuronium) and 0.2 +/- 0.03 microgram/ml (pancuronium). The disposition kinetics were adequately described by a three-compartment model. An effect compartment was added to the model to correlate the neuromuscular effects and plasma concentrations of both drugs. The ratio between concentrations of vecuronium and pancuronium in the effect compartment at 50% twitch height was 0.83. In spite of its greater potency, vecuronium has a shorter duration of action than pancuronium.
在12例妇科患者中研究了静脉输注2分钟0.1mg/kg维库溴铵或泮库溴铵（等效剂量）后的血浆浓度及神经肌肉阻滞程度。两种药物的血浆浓度均呈三相下降。两种药物的截距和速率常数差异无统计学意义。维库溴铵从血浆中清除比泮库溴铵更快；这反映在维库溴铵的血浆清除率显著更高（维库溴铵为4ml·min⁻¹·kg⁻¹，泮库溴铵为1.1ml·min⁻¹·kg⁻¹）。肌颤搐高度恢复50%时的有效血浆浓度，维库溴铵为0.11±0.02，泮库溴铵为0.2±0.03μg/ml。三室模型能充分描述其处置动力学。在模型中增加一个效应室以关联两种药物的神经肌肉效应和血浆浓度。肌颤搐高度恢复50%时效应室中维库溴铵与泮库溴铵浓度之比为0.83。尽管维库溴铵效能更高，但其作用持续时间比泮库溴铵短。
