从一名因PRPF8基因突变导致色素性视网膜炎的患者身上生成人诱导多能干细胞系。
Generation of a human iPSC line from a patient with retinitis pigmentosa caused by mutation in PRPF8 gene.
作者信息
Lukovic Dunja, Bolinches-Amorós Arantxa, Artero-Castro Ana, Pascual Beatriz, Carballo Miguel, Hernan Imma, Erceg Slaven
机构信息
National Stem Cell Bank-Valencia Node, Biomolecular and Bioinformatics Resources Platform PRB2,ISCIII, Research Center Principe Felipe, c/Eduardo Primo Yúfera 3, 46012, Valencia, Spain.
Unitat de Genética Molecular, Hospital de Terrassa, Terrassa, Spain.
出版信息
Stem Cell Res. 2017 May;21:23-25. doi: 10.1016/j.scr.2017.03.007. Epub 2017 Mar 15.
The human iPSC cell line, RP2-FiPS4F1 (RCPFi001-A), derived from dermal fibroblasts from the patient with retinitis pigmentosa caused by the mutation of the gene PRPF8, was generated by non-integrative reprogramming technology using OCT3/4, SOX2, CMYC and KLF4 reprogramming factors.
人诱导多能干细胞系RP2-FiPS4F1（RCPFi001-A）由一名因PRPF8基因突变导致视网膜色素变性的患者的真皮成纤维细胞衍生而来，采用OCT3/4、SOX2、CMYC和KLF4重编程因子，通过非整合重编程技术产生。
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