Beal M F, Marshall P E, Burd G D, Landis D M, Martin J B
Brain Res. 1985 Dec 30;361(1-2):135-45. doi: 10.1016/0006-8993(85)91283-1.
Huntington's disease is accompanied by severe neuronal death in the striatum, but despite this cell loss, there is a marked increase in the striatal concentration of somatostatin-like immunoreactivity (SLI). We attempted to examine the mechanism of this increase by using kainic or ibotenic acid to effect a unilateral lesion in the rat neostriatum. Graded doses of toxin cause a proportional decrease in the concentration of somatostatin-like immunoreactivity to a maximum of 50% of control, which is stable over an interval of 3 months. The increased somatostatin-like immunoreactivity in Huntington's disease is not mimicked by the excitotoxin lesions in rats. In addition we find that unilateral kainic acid lesions in the striatum reduce SLI in the contralateral striatum as well, although histologic evidence and assay of choline acetyltransferase activity indicate that damage is confined to the injected side. Immunocytochemistry demonstrates a loss of somatostatin-containing neurons on the lesioned side but no discernible loss in the contralateral striatum. The bilateral decrease in SLI following unilateral lesions suggests damage to a somatostatin projection to the contralateral striatum or a compensatory interaction between the two striatal nuclei.
亨廷顿舞蹈症伴有纹状体中严重的神经元死亡，但尽管有这种细胞损失，纹状体内生长抑素样免疫反应性（SLI）的浓度却显著增加。我们试图通过使用 kainic 酸或鹅膏蕈氨酸在大鼠新纹状体中造成单侧损伤来研究这种增加的机制。不同剂量的毒素会导致生长抑素样免疫反应性浓度成比例下降，最大可降至对照值的 50%，且在 3 个月的时间间隔内保持稳定。大鼠中的兴奋性毒素损伤并未模拟出亨廷顿舞蹈症中生长抑素样免疫反应性增加的情况。此外，我们发现纹状体内单侧 kainic 酸损伤也会降低对侧纹状体中的 SLI，尽管组织学证据和胆碱乙酰转移酶活性检测表明损伤仅限于注射侧。免疫细胞化学显示损伤侧含生长抑素的神经元有所损失，但对侧纹状体中未发现明显损失。单侧损伤后 SLI 的双侧下降表明对侧纹状体的生长抑素投射受损，或者两个纹状体核之间存在代偿性相互作用。
