Beal M F, Martin J B
Brain Res. 1983 Apr 25;266(1):67-73. doi: 10.1016/0006-8993(83)91309-4.
Substantial amounts of somatostatin have been demonstrated in the basal ganglia and immunocytochemistry has demonstrated both somatostatin staining neurons and nerve terminals. In order to study possible sources of somatostatin input to the striatum a series of lesions were made. Lesions of the substantia nigra produced with either 6-hydroxydopamine or ibotenic acid and hemisections at the level of the globus pallidus (6.2 mm anterior) had no effect on striatal levels of somatostatin-like immunoreactivity (SLI). Similarly dorsal frontal or hemicortectomies had no effect on SLI in the striatum. Kainic acid injected directly into the striatum at 2 dose levels resulted in a 60% depletion of SLI on the ipsilateral side and a 25% reduction on the contralateral side. These results suggest that about half of the SLI in the striatum is localizable to intrinsic neurons; the source of the remaining SLI is presently unknown but does not appear to arise in the dorsal cortex, thalamus or brainstem.
在基底神经节中已证实存在大量生长抑素，免疫细胞化学显示了生长抑素染色的神经元和神经末梢。为了研究纹状体生长抑素输入的可能来源，进行了一系列损伤实验。用6-羟基多巴胺或鹅膏蕈氨酸造成黑质损伤，以及在苍白球水平（前6.2毫米）进行半横切，对纹状体中生长抑素样免疫反应性（SLI）水平没有影响。同样，背侧额叶切除术或大脑半球切除术对纹状体中的SLI也没有影响。以2种剂量水平将 kainic 酸直接注射到纹状体中，导致同侧SLI减少60%，对侧减少25%。这些结果表明，纹状体中约一半的SLI可定位于内在神经元；其余SLI的来源目前尚不清楚，但似乎并非起源于背侧皮质、丘脑或脑干。
