Florey J, Ewen V, Syme H
Department of Clinical Science and Services, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK.
J Small Anim Pract. 2017 Sep;58(9):531-535. doi: 10.1111/jsap.12707. Epub 2017 Jul 5.
The objectives of the study were to examine the association between diagnosis of cystine urolithiasis and entire versus neutered status in male dogs and whether the strength of association varies among breeds.
A previously reported canine urolithiasis database was used, documenting all urolith submissions to Hill's Pet Nutrition UK over a 10-year period. Uroliths were classified as cystine or non-cystine, and only male dogs with known neuter status were included in the analysis. Breeds of dog (and an additional crossbreed group), for which there was a minimum of 10 cystine urolith submissions, were analysed individually, with all other breeds combined together to form a reference group. Results were analysed using chi-squared and Fisher's exact tests. Logistic regression was used to assess associations between breed and neuter status and formation of cystine calculi.
In multiple breeds, dogs with cystine uroliths were significantly more likely to be entire than dogs forming other types of urolith. Being an entire male, regardless of breed, was associated with an increased risk of cystine urolithiasis (odds ratio=4·5; 95% confidence interval: 3·22 to 6·37; P<0·001).
Increased odds of cystine formation in entire dogs supports further investigation of castration as a method to prevent cystine urolithiasis.
本研究的目的是检查雄性犬胱氨酸尿石症诊断与未绝育状态和已绝育状态之间的关联，以及这种关联强度在不同品种之间是否存在差异。
使用一个先前报道的犬尿石症数据库，该数据库记录了10年间提交给英国希尔宠物营养公司的所有尿石样本。尿石被分类为胱氨酸或非胱氨酸，分析仅纳入已知绝育状态的雄性犬。对至少有10例胱氨酸尿石样本提交的犬种（以及一个额外的杂交犬组）进行单独分析，将所有其他犬种合并形成一个参考组。使用卡方检验和费舍尔精确检验分析结果。采用逻辑回归评估品种、绝育状态与胱氨酸结石形成之间的关联。
在多个品种中，患有胱氨酸尿石的犬比形成其他类型尿石的犬更有可能未绝育。无论品种如何，作为未绝育雄性与胱氨酸尿石症风险增加相关（比值比=4.5；95%置信区间：3.22至6.37；P<0.001）。
未绝育犬中胱氨酸形成几率增加，支持将去势作为预防胱氨酸尿石症的一种方法进行进一步研究。
