Kresovich Jacob K, Zhang Zhou, Fang Fang, Zheng Yinan, Sanchez-Guerra Marco, Joyce Brian T, Zhong Jia, Chervona Yana, Wang Sheng, Chang Dou, McCracken John P, Díaz Anaite, Bonzini Matteo, Carugno Michele, Koutrakis Petros, Kang Choong-Min, Bian Shurui, Gao Tao, Byun Hyang-Min, Schwartz Joel, Baccarelli Andrea A, Hou Lifang
a Department of Preventive Medicine , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
b Division of Epidemiology and Biostatistics, School of Public Health , University of Illinois-Chicago , Chicago , IL , USA.
Biomarkers. 2017 Sep;22(6):584-593. doi: 10.1080/1354750X.2017.1347961. Epub 2017 Jul 26.
Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear.
We examine the relationship between global histone concentrations and various markers of blood pressure.
Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, H3K9me3, H3K27me3, and H3K36me3) associations with pre- and post-work measurements of systolic (SBP) and diastolic (DBP) blood pressure, mean arterial pressure (MAP), and pulse pressure (PP) using multivariable mixed-effect models.
H3K9ac was negatively associated with pre-work SBP and MAP; H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP; and H3K27me3 was negatively associated with pre-work SBP. Among office workers, H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP. Among truck drivers, H3K9ac and H3K27me were negatively associated with pre-work SBP, and H3K27me3 was positively associated with post-work PP.
Epigenome-wide H3K9ac, H3K9me3, and H3K27me3 were negatively associated with multiple pre-work blood pressure measures. These associations substantially changed during the day, suggesting an influence of daily activities. Blood-based histone modification biomarkers are potential candidates for studies requiring estimations of morning/pre-work blood pressure.
组蛋白修饰调节基因表达；失调与心血管疾病有关。人类组蛋白修饰水平与血压之间的关联尚不清楚。
我们研究总体组蛋白浓度与各种血压标志物之间的关系。
利用北京卡车司机空气污染研究，我们使用多变量混合效应模型，调查了外周血白细胞总体组蛋白修饰（H3K9ac、H3K9me3、H3K27me3和H3K36me3）与工作前和工作后收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）和脉压（PP）测量值之间的关联。
H3K9ac与工作前SBP和MAP呈负相关；H3K9me3与工作前SBP、DBP和MAP呈负相关；H3K27me3与工作前SBP呈负相关。在办公室工作人员中，H3K9me3与工作前SBP、DBP和MAP呈负相关。在卡车司机中，H3K9ac和H3K27me与工作前SBP呈负相关，H3K27me3与工作后PP呈正相关。
全表观基因组范围内的H3K9ac、H3K9me3和H3K27me3与多种工作前血压测量值呈负相关。这些关联在一天中发生了显著变化，表明日常活动有影响。基于血液的组蛋白修饰生物标志物是需要估计早晨/工作前血压的研究的潜在候选物。
