a Shandong Gout Clinical Medical Center, The Affiliated Hospital of Qingdao University , Qingdao , China.
Clin Exp Hypertens. 2017;39(7):601-605. doi: 10.1080/10641963.2017.1299750. Epub 2017 Jul 5.
Positive association between blood pressure (BP) and uric acid is evident, but specific effect size of serum uric acid (SUA) at different levels on BP is unclear, and interaction effect of SUA with other metabolic factors on BP was rarely reported. A cross-sectional study was conducted by making use of data from an epidemic investigation. A total of 3658 subjects were enrolled in our data analysis. In male subjects, for each 1 mg/dL increase in the SUA level, systolic blood pressure (SBP) and diastolic blood pressure (DBP) increased by 1.339 mmHg [95% CI: 0.552-2.126] and 0.515 mmHg [95% CI: 0.013-1.016], respectively, after adjusting for age, fasting plasma glucose (FPG), triglyceride (TG), total cholesterol (TC), estimated-glomerular filtration rate (eGFR), body mass index (BMI), drinking, smoking, and waist-hip ratio (WHR). And in female subjects, for each 1 mg/dL increase in the SUA level, SBP and DBP increased by 1.180 mmHg [95% CI: 0.401-1.959] and 0.549 mmHg [95% CI: 0.086-1.011], respectively, after adjusting the same factors. In males, in subjects with SUA < 6 mg/dL, SBP increased by 0.585 mmHg [95% CI: -0.976 to 2.146] for each 1 mg/dL increase in the SUA level, while in subjects with SUA ≥ 6 mg/dL, SBP increased by 3.271 mmHg [95% CI: 1.244-5.297] (p interaction = 0.0369), after adjusting age, BMI, smoking, drinking, TG, TC, FPG, eGFR, and WHR. This difference was not observed in DBP and females. Interaction effects between SUA and BMI, TG, FPG on BP were discovered. In conclusion, higher level of SUA has a stronger effect on BP and other metabolic factors: FPG, TG, and BMI could strengthen the effect of SUA on BP.
尿酸与血压呈正相关，但血清尿酸（SUA）在不同水平对血压的具体影响大小尚不清楚，SUA 与其他代谢因素对血压的交互作用也鲜有报道。本研究利用一项流行病学调查数据进行了横断面研究。共纳入 3658 例受试者进行数据分析。在男性中，SUA 水平每增加 1mg/dL，收缩压（SBP）和舒张压（DBP）分别增加 1.339mmHg（95%CI：0.552-2.126）和 0.515mmHg（95%CI：0.013-1.016），校正年龄、空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、估算肾小球滤过率（eGFR）、体重指数（BMI）、饮酒、吸烟和腰臀比（WHR）后。在女性中，SUA 水平每增加 1mg/dL，SBP 和 DBP 分别增加 1.180mmHg（95%CI：0.401-1.959）和 0.549mmHg（95%CI：0.086-1.011），校正相同因素后。在男性中，SUA<6mg/dL 的受试者中，SUA 水平每增加 1mg/dL，SBP 增加 0.585mmHg（95%CI：-0.976-2.146），而 SUA≥6mg/dL 的受试者中，SBP 增加 3.271mmHg（95%CI：1.244-5.297）（p 交互=0.0369），校正年龄、BMI、吸烟、饮酒、TG、TC、FPG、eGFR 和 WHR 后。这种差异在 DBP 和女性中没有观察到。还发现了 SUA 与 BMI、TG、FPG 对 BP 的交互作用。总之，较高水平的 SUA 对 BP 和其他代谢因素（FPG、TG 和 BMI）的影响更大：FPG、TG 和 BMI 可以增强 SUA 对 BP 的影响。
