a Department of Oncology , Cancer Center of People's Liberation Army, General Hospital of Shenyang, Military Region , Shenyang , P.R. China.
b Department of Clinical Pharmacy , Shenyang Pharmaceautical University , Shenyang , P.R. China.
Cancer Biol Ther. 2017 Sep 2;18(9):635-639. doi: 10.1080/15384047.2017.1345394. Epub 2017 Jul 5.
Pancreatic liposarcoma is a malignant tumor originated from the pancreas mesenchymal tissue and mostly presented in skin, subcutaneous, periosteum, and long bone on both sides. Both conventional chemotherapy and radiotherapy have limited efficacy and poor prognosis for advanced pancreatic liposarcoma. Here, we reported a case of advanced pancreatic liposarcoma and reviewed the literature specific for liposarcoma of the pancreas and discuss the emerging options of treatment. The patient was treated with apatinib and a cross-line rescue therapy combined with paclitaxel after progressive disease. The therapeutic effect of the combination regimen has been evaluated. Apatinib is an oral tyrosine kinase inhibitor targeting the intracellular domain of vascular endothelial growth factor receptor-2 (VEGFR-2), which has dual effects of anti-angiogenesis and anti-tumor cell proliferation. To our knowledge, this is the first case to report the successful use of apatinib for advanced pancreatic liposarcoma.
胰腺脂肪肉瘤是一种起源于胰腺间叶组织的恶性肿瘤,主要发生在皮肤、皮下组织、骨膜和双侧长骨。常规化疗和放疗对晚期胰腺脂肪肉瘤疗效有限,预后较差。我们报告了一例晚期胰腺脂肪肉瘤,并对胰腺脂肪肉瘤的文献进行了复习,讨论了治疗的新选择。患者在疾病进展后接受阿帕替尼治疗,并联合紫杉醇进行交叉线解救治疗。该联合方案的治疗效果已进行了评估。阿帕替尼是一种针对血管内皮生长因子受体-2(VEGFR-2)细胞内域的口服酪氨酸激酶抑制剂,具有抗血管生成和抗肿瘤细胞增殖的双重作用。据我们所知,这是首例报告阿帕替尼成功用于治疗晚期胰腺脂肪肉瘤的病例。