高危饮酒与艾滋病毒/艾滋病成年感染者的抗逆转录病毒治疗不依从性有关。
At-Risk Alcohol Use is Associated with Antiretroviral Treatment Nonadherence Among Adults Living with HIV/AIDS.
作者信息
Paolillo Emily W, Gongvatana Assawin, Umlauf Anya, Letendre Scott L, Moore David J
机构信息
Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, California.
HIV Neurobehavioral Research Program, Department of Psychiatry, University of California, San Diego, San Diego, California.
出版信息
Alcohol Clin Exp Res. 2017 Aug;41(8):1518-1525. doi: 10.1111/acer.13433. Epub 2017 Jul 5.
Abstract
BACKGROUND
Alcohol use is a risk factor for nonadherence to antiretroviral therapy (ART) among people living with HIV/AIDS (PLWHA); however, differences in ART adherence across levels of alcohol use are unclear. This study examined whether "at-risk" alcohol use, defined by National Institute of Alcohol Abuse and Alcoholism guidelines, was associated with ART nonadherence among PLWHA.
METHODS
Participants were 535 HIV-infected adults enrolled in studies at the HIV Neurobehavioral Research Program. ART nonadherence was identified by either self-reported missed dose or plasma viral load detectability (≥50 copies/ml). Potential covariates for multivariable logistic regression included demographics, depression, and substance use disorders.
RESULTS
Using a stepwise model selection procedure, we found that at-risk alcohol use (OR = 0.64; p = 0.032) and low education (OR = 1.09 per 1 year increase in education; p = 0.009) significantly predict lower ART adherence.
CONCLUSIONS
A greater focus on the treatment of at-risk alcohol use may improve ART adherence among HIV-infected persons.
摘要
背景
饮酒是艾滋病毒/艾滋病感染者（PLWHA）抗逆转录病毒治疗（ART）依从性差的一个风险因素；然而，不同饮酒水平的ART依从性差异尚不清楚。本研究调查了根据美国国立酒精滥用与酒精中毒研究所指南定义的“有风险”饮酒是否与PLWHA的ART不依从性相关。
方法
参与者为535名感染艾滋病毒的成年人，他们参与了艾滋病毒神经行为研究项目的研究。通过自我报告的漏服剂量或血浆病毒载量可检测性（≥50拷贝/毫升）来确定ART不依从性。多变量逻辑回归的潜在协变量包括人口统计学、抑郁症和物质使用障碍。
结果
使用逐步模型选择程序，我们发现有风险饮酒（OR = 0.64；p = 0.032）和低教育水平（每增加1年教育，OR = 1.09；p = 0.009）显著预测较低的ART依从性。
结论
更多地关注有风险饮酒的治疗可能会提高艾滋病毒感染者的ART依从性。
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2
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3
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