Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21205, USA.
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA.
AIDS Behav. 2021 Apr;25(4):1072-1082. doi: 10.1007/s10461-020-03065-z. Epub 2020 Oct 16.
We examined HIV viral load non-suppression ([Formula: see text] 200 copies/mL) subsequent to person-periods (3-18 months) bookended by two self-reports of alcohol use on a standardized patient reported outcome assessment among adults in routine HIV care. We examined the relative risk (RR) of non-suppression associated with increases and decreases in alcohol use (relative to stable use), stratified by use at the start of the person-period. Increases in drinking from abstinence were associated with higher risk of viral non-suppression (low-risk without binge: RR 1.16, 95% CI 1.03, 1.32; low-risk with binge: RR 1.35, 95% CI 1.11, 1.63; high-risk: RR 1.89, 95% CI 1.16, 3.08). Decreases in drinking from high-risk drinking were weakly, and not statistically significantly associated with lower risk of viral non-suppression. Other changes in alcohol use were not associated with viral load non-suppression. Most changes in alcohol consumption among people using alcohol at baseline were not strongly associated with viral non-suppression.
我们在常规 HIV 护理中，通过对成年人的标准化患者报告结果评估，检查了在两段自我报告的酒精使用（[Formula: see text] 200 拷贝/毫升）之后的 HIV 病毒载量抑制失败（[Formula: see text] 200 拷贝/毫升）的情况。我们检查了与酒精使用增加和减少相关的非抑制风险比（RR）（与稳定使用相比），按人期间开始时的使用情况进行分层。从禁欲开始饮酒增加与病毒抑制失败的风险增加相关（低危无狂欢：RR 1.16，95%CI 1.03，1.32；低危狂欢：RR 1.35，95%CI 1.11，1.63；高危：RR 1.89，95%CI 1.16，3.08）。从高危饮酒减少饮酒与病毒非抑制风险降低的相关性较弱，且无统计学意义。其他饮酒变化与病毒载量非抑制无关。在基线饮酒的人中，大多数饮酒量的变化与病毒非抑制无明显关联。
