三氧化二砷可减少调节性T细胞的数量并抑制其功能，这可能有助于其在急性早幼粒细胞白血病治疗中的疗效。

Arsenic trioxide decreases the amount and inhibits the function of regulatory T cells, which may contribute to its efficacy in the treatment of acute promyelocytic leukemia.

作者信息

Xu Wen, Li Xiaoxia, Quan Lina, Yao Jiying, Mu Guannan, Guo Jingjie, Wang Yitong

机构信息

a Department of Immunology , Harbin Medical University , Harbin , People's Republic of China.

b Department of Hematology , The First Affiliated Hospital of Harbin Medical University , Harbin , People's Republic of China.

出版信息

Leuk Lymphoma. 2018 Mar;59(3):650-659. doi: 10.1080/10428194.2017.1346253. Epub 2017 Jul 6.

DOI:10.1080/10428194.2017.1346253

PMID:28679299

Abstract

Arsenic trioxide (ATO) exhibits substantial clinical efficacy in the treatment of acute promyelocytic leukemia (APL). Here, we investigated whether ATO exerts its efficacy by affecting regulatory T (Treg) cells. We determined whether ATO treatment influenced the amount and function of purified Treg cells. We also examined the effect of ATO treatment on Treg cells from APL patients. ATO treatment induced apoptosis in purified Treg cells and dampened the inhibition of effector T (Teff) cells proliferation and the secretion of cytokine by Treg cells. Treg cell levels in the peripheral blood and serum IL-10 levels were dramatically decreased in APL patients after single ATO treatment. In summary, our results show that ATO decreases the amount and inhibits the function of Treg cells, thereby enhancing Teff cell function and overall anti-tumor immunity.

摘要

三氧化二砷（ATO）在急性早幼粒细胞白血病（APL）的治疗中显示出显著的临床疗效。在此，我们研究了ATO是否通过影响调节性T（Treg）细胞发挥其疗效。我们确定了ATO治疗是否会影响纯化的Treg细胞的数量和功能。我们还研究了ATO治疗对APL患者Treg细胞的影响。ATO治疗可诱导纯化的Treg细胞凋亡，并减弱Treg细胞对效应T（Teff）细胞增殖的抑制作用以及细胞因子的分泌。单次ATO治疗后，APL患者外周血中的Treg细胞水平和血清IL-10水平显著降低。总之，我们的结果表明，ATO可减少Treg细胞的数量并抑制其功能，从而增强Teff细胞功能和整体抗肿瘤免疫力。