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High endocan levels are associated with the need for mechanical ventilation among patients with severe sepsis.

作者信息

Mangat Mandeep, Amalakuhan Bravein, Habib Sheila, Reyes Luis F, Hinojosa Cecilia A, Rodriguez Alejandro H, Soni Nilam J, Anzueto Antonio, Levine Stephanie M, Peters Jay I, Aliberti Stefano, Sibila Oriol, Rello Jordi, Witzenrath Martin, Waterer Grant W, Martin-Loeches Ignacio, Blanquer Jose, Sanz Francisco, Marcos Pedro J, Solé-Violán Jordi, Chalmers James D, Feldman Charles, Wunderink Richard G, Cruz Charles S Dela, Orihuela Carlos J, Restrepo Marcos I

机构信息

University of Texas Health Science Center San Antonio, San Antonio, TX, USA.

South Texas Veterans Health Care System, San Antonio, TX, USA.

出版信息

Eur Respir J. 2017 Jul 5;50(1). doi: 10.1183/13993003.00013-2017. Print 2017 Jul.

DOI:10.1183/13993003.00013-2017
PMID:28679609
Abstract
摘要

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1
High endocan levels are associated with the need for mechanical ventilation among patients with severe sepsis.高内皮抑素水平与严重脓毒症患者机械通气需求相关。
Eur Respir J. 2017 Jul 5;50(1). doi: 10.1183/13993003.00013-2017. Print 2017 Jul.
2
Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan.糖萼生物标志物 syndecan-1 比内脂素更能预测因肺炎导致脓毒症的患者发生呼吸衰竭。
J Crit Care. 2018 Oct;47:93-98. doi: 10.1016/j.jcrc.2018.06.015. Epub 2018 Jun 18.
3
Low endocan levels are predictive of Acute Respiratory Distress Syndrome in severe sepsis and septic shock.低内皮细胞水平可预测严重脓毒症和感染性休克所致急性呼吸窘迫综合征。
J Crit Care. 2018 Oct;47:121-126. doi: 10.1016/j.jcrc.2018.06.018. Epub 2018 Jun 20.
4
Endothelial cell-specific molecule-1/endocan: Diagnostic and prognostic value in patients suffering from severe sepsis and septic shock.内皮细胞特异性分子-1/内皮糖蛋白：对严重脓毒症和脓毒性休克患者的诊断及预后价值
J Crit Care. 2016 Feb;31(1):68-75. doi: 10.1016/j.jcrc.2015.09.019. Epub 2015 Sep 25.
5
The complex kinetics of blood endocan during the time course of sepsis and acute respiratory distress syndrome.脓毒症和急性呼吸窘迫综合征病程中血液内脂素的复杂动力学。
Crit Care. 2019 Mar 12;23(1):86. doi: 10.1186/s13054-019-2383-z.
6
Effect of a novel extracorporeal cytokine apheresis method on endocan, copeptin And interleukin-6 levels in sepsis: An observational prospective study.新型体外细胞因子清除法对脓毒症中内皮细胞蛋白 C 反应蛋白、copeptin 和白细胞介素-6 水平的影响：一项观察性前瞻性研究。
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Endocan, a new endothelial marker in human sepsis.内皮糖蛋白，一种人类脓毒症中的新型内皮标志物。
Crit Care Med. 2006 Feb;34(2):532-7. doi: 10.1097/01.ccm.0000198525.82124.74.
8
Endocan and Soluble Triggering Receptor Expressed on Myeloid Cells-1 as Novel Markers for Neonatal Sepsis.内皮抑素和髓系细胞表面表达的可溶性触发受体-1作为新生儿败血症的新型标志物
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Concentration and value of endocan on outcome in adult patients after severe sepsis.严重脓毒症成人患者预后的内脂素浓度及其价值。
Clin Chim Acta. 2018 Aug;483:275-280. doi: 10.1016/j.cca.2018.05.007. Epub 2018 May 8.
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Endocan elicits severe vascular inflammatory responses in vitro and in vivo.内钙蛋白在体外和体内引起严重的血管炎症反应。
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引用本文的文献

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Endothelial dysfunction and immunothrombosis in sepsis.脓毒症中的内皮功能障碍与免疫血栓形成。
Front Immunol. 2023 Apr 4;14:1144229. doi: 10.3389/fimmu.2023.1144229. eCollection 2023.
2
Endothelitis profile in acute heart failure and cardiogenic shock patients: Endocan as a potential novel biomarker and putative therapeutic target.急性心力衰竭和心源性休克患者的内皮炎症特征：内皮糖蛋白作为一种潜在的新型生物标志物和假定的治疗靶点。
Front Physiol. 2022 Aug 11;13:965611. doi: 10.3389/fphys.2022.965611. eCollection 2022.
3
Endocan as a potential marker in diagnosis and predicting disease severity in COVID-19 patients: a promising biomarker for patients with false-negative RT-PCR.
内脂素作为 COVID-19 患者诊断和预测疾病严重程度的潜在标志物：一种对 RT-PCR 假阴性患者有前途的生物标志物。
Ups J Med Sci. 2022 Jan 24;12. doi: 10.48101/ujms.v127.8211. eCollection 2022.
4
Novel Perspectives Regarding the Pathology, Inflammation, and Biomarkers of Acute Respiratory Distress Syndrome.关于急性呼吸窘迫综合征的病理学、炎症和生物标志物的新观点。
Int J Mol Sci. 2020 Dec 28;22(1):205. doi: 10.3390/ijms22010205.
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Endocan Is an Independent Predictor of Heart Failure-Related Mortality and Hospitalizations in Patients with Chronic Stable Heart Failure.内皮细胞蛋白聚糖是慢性稳定型心力衰竭患者心力衰竭相关死亡率和住院率的独立预测因子。
Dis Markers. 2019 Apr 4;2019:9134096. doi: 10.1155/2019/9134096. eCollection 2019.
6
Endocan, sepsis, pneumonia, and acute respiratory distress syndrome.内消蛋白、脓毒症、肺炎和急性呼吸窘迫综合征。
Crit Care. 2018 Oct 26;22(1):280. doi: 10.1186/s13054-018-2222-7.