Tamarit-Rodriguez J, Vara E, Tamarit J
Horm Metab Res. 1985 Dec;17(12):623-5. doi: 10.1055/s-2007-1013628.
The specificity of a new somatostatin antiserum (Ab 6) has been investigated using eight different peptide analogues. For this purpose, somatostatin and all the analogues were tested, in an equimolar concentration range, for their ability to displace 125I-tyr1-somatostatin from its binding to antibodies. Analysis of the displacement curves shows that antiserum Ab 6 predominantly recognizes changes at the central aminoacid sequence of the somatostatin molecule. Its ligand specificity seems to be similar to that of other somatostatin antisera previously described (R-141 and A-101).
已使用八种不同的肽类似物研究了一种新型生长抑素抗血清（Ab 6）的特异性。为此，在等摩尔浓度范围内测试了生长抑素和所有类似物从其与抗体的结合中置换125I-酪氨酸1-生长抑素的能力。对置换曲线的分析表明，抗血清Ab 6主要识别生长抑素分子中央氨基酸序列的变化。其配体特异性似乎与先前描述的其他生长抑素抗血清（R-141和A-101）相似。
