缓解期双相情感障碍患者大脑半球间功能连接的改变：一项静息态 fMRI 研究。
Altered interhemispheric functional connectivity in remitted bipolar disorder: A Resting State fMRI Study.
机构信息
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Department of Radiology, Gansu Provincial Hospital, Gansu, 730000, China.
出版信息
Sci Rep. 2017 Jul 5;7(1):4698. doi: 10.1038/s41598-017-04937-6.
Abnormalities in structural and functional brain connectivity have been increasingly reported in patients with bipolar disorder (BD). However, alterations of remitted BD (RBD) in functional connectivity between the cerebral hemispheres are still not well understood. This study was designed to analyze the pattern of the interhemispheric functional connectivity of the whole brain in patients with remitted BD during resting state. Twenty patients with RBD and 38 healthy controls (HC) underwent the resting-state functional magnetic resonance imaging. The functional connectivity between any pair of symmetrical interhemispheric voxels (i.e., functional homotopy) was measured by voxel-mirrored homotopic connectivity (VMHC). The patients with RBD showed lower VMHC than HC in the middle frontal gyrus and precentral gyrus. No regions of increased VMHC were detected in the RBD patients. There were no significant correlations between the VMHC values in these regions and the clinical variables. These findings suggest substantial impairment of interhemispheric coordination in RBD and they may represent trait, rather than state, neurobiological feature of brain function in BD.
异常的结构和功能连接已在双相情感障碍（BD）患者中越来越多地报道。然而，缓解期双相情感障碍（RBD）的大脑半球间功能连接的改变仍不清楚。本研究旨在分析缓解期 BD 患者静息状态下全脑半球间功能连接的模式。20 例 RBD 患者和 38 例健康对照（HC）接受静息状态功能磁共振成像。通过体素镜像同伦连接（VMHC）测量任何一对对称的大脑半球间体素（即功能同伦）之间的功能连接。与 HC 相比，RBD 患者的额中回和中央前回的 VMHC 较低。在 RBD 患者中未发现 VMHC 增加的区域。这些区域的 VMHC 值与临床变量之间无显著相关性。这些发现表明 RBD 中大脑半球间协调的严重损害，它们可能代表 BD 中大脑功能的特质，而不是状态的神经生物学特征。
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