Wang Y, Zhong S, Jia Y, Zhou Z, Zhou Q, Huang L
Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Acta Psychiatr Scand. 2015 Nov;132(5):400-7. doi: 10.1111/acps.12429. Epub 2015 Apr 30.
Abnormalities in structural and functional brain connectivity have been increasingly reported in patients with bipolar disorder (BD) by recent neuroimaging studies. However, relatively little is known about the changes in functional interaction between the cerebral hemispheres in BD. The present study aimed to examine the interhemispheric functional connectivity of the whole brain in patients with BD II during resting state.
Twenty-six patients with unmedicated BD II depression and 40 normal controls underwent the resting-state functional magnetic resonance imaging. The functional connectivity between any pair of symmetrical interhemispheric voxels (i.e., functional homotopy) was measured by voxel-mirrored homotopic connectivity (VMHC).
The patients with BD II showed lower VMHC than normal controls in the medial prefrontal cortex and inferior temporal gyrus. No regions of increased VMHC were detected in patients. There were no significant correlations between the VMHC values in these regions and clinical severity of BD symptoms.
These findings suggest substantial impairment of interhemispheric coordination in BD II.
近期的神经影像学研究越来越多地报道双相情感障碍（BD）患者存在大脑结构和功能连接异常。然而，对于BD患者大脑半球间功能相互作用的变化了解相对较少。本研究旨在检查处于静息状态的II型双相情感障碍患者全脑的半球间功能连接。
26例未用药的II型双相情感障碍抑郁患者和40名正常对照者接受静息态功能磁共振成像。通过体素镜像同伦连接（VMHC）测量任意一对对称半球间体素之间的功能连接（即功能同伦）。
II型双相情感障碍患者在内侧前额叶皮质和颞下回的VMHC低于正常对照者。未在患者中检测到VMHC增加的区域。这些区域的VMHC值与BD症状的临床严重程度之间无显著相关性。
这些发现表明II型双相情感障碍患者半球间协调存在严重损害。
