Mentese Ahmet, Fidan Evren, Alver Ahmet, Demir Selim, Yaman Serap Ozer, Sumer Aysegul, Fidan Sami, Kavgaci Halil, Turan Ibrahim
Program of Medical Laboratory Techniques, Vocational School of Health Sciences, Karadeniz Technical University, Trabzon, Turkey.
Department of Internal Medicine and Medical Oncology, Kanuni Teaching and Research Hospital, Trabzon, Turkey.
Cent Eur J Immunol. 2017;42(1):73-77. doi: 10.5114/ceji.2017.67320. Epub 2017 May 8.
Cancer is the second leading cause of death and gastric cancer is the fourth most common cancer type worldwide. Investigation of autoantibodies in cancer patients has been a popular research area in recent years. The aim of the current study was to investigate carbonic anhydrase I and II (CA I and II) autoantibodies in the plasma of subjects with gastric cancer based on the information and considerations of autoimmune relation of gastric cancer. Anti-CA I and II antibody levels were investigated by ELISA in plasma samples of fifty two patients with gastric cancer and thirty five healthy peers. Anti-CA I and II antibody titers of the gastric cancer group were significantly higher compared with the control group (p = 0.004, p = 0.0001, respectively). Plasma anti-CA I levels of the metastatic group were lower than the non-metastatic group and this difference was found statistically significant (p < 0.05), but there was no statistical difference between plasma anti-CA II levels of the groups. CA I and II autoantibody titers in patients with gastric cancer were found higher compared to healthy subjects and the results suggest that these autoantibodies may be involved in the pathogenesis of gastric cancer.
癌症是全球第二大致死原因，胃癌是第四大常见癌症类型。近年来，对癌症患者自身抗体的研究一直是热门研究领域。基于胃癌自身免疫关系的信息和考虑，本研究旨在调查胃癌患者血浆中的碳酸酐酶I和II（CA I和II）自身抗体。采用酶联免疫吸附测定法（ELISA）检测了52例胃癌患者和35名健康对照者血浆样本中的抗CA I和II抗体水平。胃癌组的抗CA I和II抗体滴度显著高于对照组（分别为p = 0.004，p = 0.0001）。转移组的血浆抗CA I水平低于非转移组，且差异具有统计学意义（p < 0.05），但两组血浆抗CA II水平之间无统计学差异。与健康受试者相比，胃癌患者的CA I和II自身抗体滴度更高，结果表明这些自身抗体可能参与了胃癌的发病机制。
