可变RNA剪接在肝脏疾病发病机制中的作用
Alternative RNA Splicing in the Pathogenesis of Liver Disease.
作者信息
Webster Nicholas J G
机构信息
Medical Research Service, VA San Diego Healthcare System, San Diego, CA, United States.
Department of Medicine, School of Medicine, Moores Cancer Center, University of California San Diego, La Jolla, CA, United States.
出版信息
Front Endocrinol (Lausanne). 2017 Jun 21;8:133. doi: 10.3389/fendo.2017.00133. eCollection 2017.
Abstract
Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent due to the worldwide obesity epidemic and currently affects one-third of adults or about one billion people worldwide. NAFLD is predicted to affect over 50% of the world's population by the end of the next decade. It is the most common form of liver disease and is associated with increased risk for progression to a more severe form non-alcoholic steatohepatitis, as well as insulin resistance, type 2 diabetes mellitus, cirrhosis, and eventually hepatocellular carcinoma. This review article will focus on the role of alternative splicing in normal liver physiology and dysregulation in liver disease.
摘要
由于全球肥胖症流行，非酒精性脂肪性肝病（NAFLD）正变得越来越普遍，目前影响着全球三分之一的成年人，约10亿人。预计到下一个十年末，NAFLD将影响全球超过50%的人口。它是最常见的肝病形式，与进展为更严重形式的非酒精性脂肪性肝炎、胰岛素抵抗、2型糖尿病、肝硬化以及最终的肝细胞癌的风险增加有关。这篇综述文章将聚焦于可变剪接在正常肝脏生理中的作用以及在肝病中的失调。
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本文引用的文献
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