脂肪性肝病中的可变剪接。
Alternative RNA Splicing in Fatty Liver Disease.
机构信息
Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, La Jolla, CA, United States.
University of California Los Angeles, Los Angeles, CA, United States.
出版信息
Front Endocrinol (Lausanne). 2021 Feb 26;12:613213. doi: 10.3389/fendo.2021.613213. eCollection 2021.
Abstract
Alternative RNA splicing is a process by which introns are removed and exons are assembled to construct different RNA transcript isoforms from a single pre-mRNA. Previous studies have demonstrated an association between dysregulation of RNA splicing and a number of clinical syndromes, but the generality to common disease has not been established. Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease affecting one-third of adults worldwide, increasing the risk of cirrhosis and hepatocellular carcinoma (HCC). In this review we focus on the change in alternative RNA splicing in fatty liver disease and the role for splicing regulation in disease progression.
摘要
选择性 RNA 剪接是一个将内含子切除并将外显子拼接在一起的过程，该过程从单个前体 mRNA 构建不同的 RNA 转录本异构体。之前的研究已经证明了 RNA 剪接的失调与许多临床综合征之间存在关联，但尚未确定其在常见疾病中的普遍性。非酒精性脂肪性肝病 (NAFLD) 是影响全球三分之一成年人的最常见肝脏疾病，增加了肝硬化和肝细胞癌 (HCC) 的风险。在这篇综述中，我们重点关注脂肪性肝病中选择性 RNA 剪接的变化以及剪接调控在疾病进展中的作用。
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