Sakr Riwa, Massoud Marcel, Aftimos Georges, Chahine Georges
Department of Hematology-Oncology, Centre Hospitalier Universitaire Notre Dame des Secours, Byblos, Lebanon.
Department of Hematology-Oncology, Faculty of Medical Sciences, Holy Spirit University of Kaslik, Jounieh, Lebanon.
J Gastric Cancer. 2017 Jun;17(2):180-185. doi: 10.5230/jgc.2017.17.e11. Epub 2017 Mar 22.
Despite the decreasing incidence and mortality from gastric cancer, it remains a major health problem worldwide. Ninety percent of cases are adenocarcinomas. Here, we report a case of gastric adenocarcinoma developed after successful treatment of prior primary gastric diffuse large B-cell lymphoma (DLBCL). Our patient was an elderly man with primary gastric DLBCL in whom complete remission was achieved after R-CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone plus rituximab) chemotherapy. infection persisted despite adequate treatment leading to sustained chronic gastritis. The mean time to diagnose metachronous gastric carcinoma was seven years. We believe that a combination of many risk factors, of which chronic infection the most important, led to the development of gastric carcinoma following primary gastric lymphoma. In summary, patients who have been successfully treated for primary gastric lymphoma should be followed up at regular short intervals. infection should be diagnosed promptly and treated aggressively.
尽管胃癌的发病率和死亡率在下降，但它仍然是全球主要的健康问题。90%的病例为腺癌。在此，我们报告一例先前原发性胃弥漫性大B细胞淋巴瘤（DLBCL）成功治疗后发生胃腺癌的病例。我们的患者是一名患有原发性胃DLBCL的老年男性，在接受R-CHOP（环磷酰胺、阿霉素、长春新碱、泼尼松龙加利妥昔单抗）化疗后实现了完全缓解。尽管进行了充分治疗，但感染持续存在，导致持续性慢性胃炎。异时性胃癌的平均诊断时间为7年。我们认为，多种危险因素共同作用，其中慢性感染最为重要，导致原发性胃淋巴瘤后发生胃癌。总之，原发性胃淋巴瘤成功治疗的患者应定期进行短期随访。应及时诊断感染并积极治疗。
