药物向近端结肠的递送。
Drug delivery to the proximal colon.
作者信息
Hardy J G, Wilson C G, Wood E
出版信息
J Pharm Pharmacol. 1985 Dec;37(12):874-7. doi: 10.1111/j.2042-7158.1985.tb04992.x.
Abstract
The transits of a capsule and a multiparticulate pellet system have been monitored through the gastrointestinal tract in six healthy volunteers. Both preparations moved together through the stomach and small intestine, reaching the colon, on average, 4 h after dosing. Within the colon the pellets dispersed and moved at a slower rate than the capsule. There was considerable intersubject variability in the large bowel transit times. The findings are discussed in terms of drug delivery to the colon.
摘要
在六名健康志愿者中监测了胶囊和多颗粒微丸系统在胃肠道中的转运情况。两种制剂一起通过胃和小肠，给药后平均4小时到达结肠。在结肠内，微丸分散并以比胶囊更慢的速度移动。大肠转运时间存在相当大的个体间差异。从药物向结肠的递送方面对这些发现进行了讨论。
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