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含凤梨科水醇提取物的光防护水包油乳剂的研制与评价

Development and Evaluation of Photoprotective O/W Emulsions Containing Hydroalcoholic Extract of (Bromeliaceae).

作者信息

de Oliveira-Júnior Raimundo Gonçalves, Souza Grasielly Rocha, Ferraz Christiane Adrielly Alves, de Oliveira Ana Paula, Araújo Camila de Souza, de Lima-Saraiva Sarah Raquel Gomes, Reis Silvio Alan Gonçalves Bomfim, Gonçalves Talita Mota, Rolim Larissa Araújo, Rolim-Neto Pedro José, César Francine Celise Siqueira, Almeida Jackson Roberto Guedes da Silva

机构信息

Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil.

Universidade Federal do Pernambuco, 50.670-901 Recife, PE, Brazil.

出版信息

ScientificWorldJournal. 2017;2017:5019458. doi: 10.1155/2017/5019458. Epub 2017 Jun 7.

Abstract

is a Bromeliaceae plant species widely found in Brazil with several pharmacological properties, including photoprotective activity. Although herbal-based active ingredients have been applied in cosmetic products, especially for skin treatment, its application in sunscreen formulations remains unexplored. The aim of this work is to evaluate the photoprotective effect of cosmetic formulations containing hydroalcoholic extract of (Nv-HA). Initially, the phenolic and flavonoid total content of Nv-HA were determined. The photoprotective activity of Nv-HA was subsequently assessed using a spectrophotometric method. Nv-HA was incorporated in O/W emulsions in the presence or absence of synthetic filters and their photoprotective efficacy was evaluated by spectrophotometric SPF determination. Finally, the stability study of the formulations was performed through the freezing/defrosting method. Nv-HA showed significant phenolic and flavonoids content (61.66 ± 5.14 mg GAE/g and 90.27 ± 5.03 mg CE/g, resp.). Nv-HA showed SPF values of 5.43 ± 0.07 and 11.73 ± 0.04 for the concentrations of 0.5 and 1.0% (v/v), respectively. It was verified that Nv-HA potentiated the photoprotective effect of formulations containing only synthetic filters. Furthermore, the formulations have remained stable at the end of the preliminary stability study. According to the results, it was concluded that Nv-HA can be used as a chemical filter in cosmetic formulations.

摘要

是一种广泛分布于巴西的凤梨科植物物种,具有多种药理特性,包括光保护活性。尽管基于草药的活性成分已应用于化妆品中,尤其是用于皮肤治疗,但其在防晒配方中的应用仍未得到探索。这项工作的目的是评估含有[具体植物名称]水醇提取物(Nv-HA)的化妆品配方的光保护作用。首先,测定了Nv-HA中酚类和黄酮类的总含量。随后,使用分光光度法评估了Nv-HA的光保护活性。在有或没有合成滤光剂的情况下,将Nv-HA加入水包油乳液中,并通过分光光度法测定SPF来评估其光保护功效。最后,通过冷冻/解冻法对配方进行稳定性研究。Nv-HA显示出显著的酚类和黄酮类含量(分别为61.66±5.14毫克没食子酸当量/克和90.27±5.03毫克儿茶素当量/克)。对于浓度为0.5%(v/v)和1.0%(v/v)的Nv-HA,其SPF值分别为5.43±0.07和11.73±0.04。证实了Nv-HA增强了仅含有合成滤光剂的配方的光保护作用。此外,在初步稳定性研究结束时,配方保持稳定。根据结果得出结论,Nv-HA可作为化妆品配方中的化学滤光剂。 (注:原文中“(Nv-HA)”前的植物名称缺失,翻译时保留了该格式)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/522f/5478885/36e9cd0cf4f7/TSWJ2017-5019458.001.jpg

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