Chadeganipour M, Mohammadi R
Department of Medical Parasitology and Mycology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Curr Med Mycol. 2015 Jun;1(2):46-52. doi: 10.18869/acadpub.cmm.1.2.46.
It has been shown that some of the mycotic infections especially systemic mycoses show increased male susceptibility and some steroids have been known to influence the immune response. Researchers found that some fungi including yeasts use "message molecules" including hormones to elicit certain responses, especially in the sexual cycle, but until recently no evidence was available to link specific hormonal evidence to this pronounced sex ratio. More evidence needed to demonstrate that a steroid (s) might in some manner influence the pathogenicity of the fungus in vivo. Therefore, the aim of this review paper is to shed some light on this subject along with effort to make mycologists more aware of this research as a stimulus for the explore of new ideas and design further research in this area of medical mycology.
已经表明，一些真菌感染尤其是系统性真菌病显示男性易感性增加，并且已知一些类固醇会影响免疫反应。研究人员发现，包括酵母在内的一些真菌使用包括激素在内的“信息分子”来引发某些反应，尤其是在有性周期中，但直到最近还没有证据将特定的激素证据与这种明显的性别比例联系起来。需要更多证据来证明某种类固醇可能以某种方式影响真菌在体内的致病性。因此，这篇综述文章的目的是阐明这个主题，同时努力让真菌学家更加了解这项研究，以此作为探索新想法和设计该医学真菌学领域进一步研究的一种激励。
