Kubota K, Sugaya K, Fujii F, Itonaga M, Sunagane N
Jpn J Pharmacol. 1985 Oct;39(2):274-6. doi: 10.1254/jjp.39.274.
The contractile response of the guinea-pig gallbladder to cholecystokinin (CCK) and acetylcholine (ACh) was irreversibly inhibited by 5 X 10(-5) M dibenamine, and the dibenamine-induced inhibition in the CCK response was prevented by 10(-4) M chlordiazepoxide (CDP) and diazepam (DZP), but not by 10(-2) M proglumide or 10(-6) M atropine. The dibenamine-induced inhibition in the ACh response was prevented by 10(-6) M atropine, but not by 10(-4) M CDP. These findings suggest that the binding of CCK to the CCK receptor can be inhibited by benzodiazepines.
豚鼠胆囊对胆囊收缩素（CCK）和乙酰胆碱（ACh）的收缩反应可被5×10⁻⁵ M的二苄胺不可逆地抑制，且二苄胺对CCK反应的抑制作用可被10⁻⁴ M的氯氮䓬（CDP）和地西泮（DZP）阻断，但不能被10⁻² M的丙谷胺或10⁻⁶ M的阿托品阻断。二苄胺对ACh反应的抑制作用可被10⁻⁶ M的阿托品阻断，但不能被10⁻⁴ M的CDP阻断。这些发现表明苯二氮䓬类药物可抑制CCK与CCK受体的结合。
