收缩期高血压相关单核苷酸多态性与缺血性脑卒中易感性相关。
Systolic hypertension related single nucleotide polymorphism is associated with susceptibility of ischemic stroke.
机构信息
Department of Hematology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
出版信息
Eur Rev Med Pharmacol Sci. 2017 Jun;21(12):2901-2906.
OBJECTIVE
Isolated systolic hypertension (ISH) is the most important risk factor for ischemic stroke. Genetic variants influencing hypertension can also be risk factors for ischemic stroke. Here, we examined the how single nucleotide polymorphisms (SNPs) associated with blood pressure impact the risk for ischemic stroke.
PATIENTS AND METHODS
We selected 300 ischemic stroke patients and 300 controls. Then, we genotyped three single nucleotide polymorphisms associated with systolic hypertension in both groups.
RESULTS
Logistic regression analysis showed that the rs11099098 genotype was associated with a significantly decreased risk of IS (Dominant model: OR = 0.55, 95% CI = 0.37-0.82, p = 0.003). Two other SNPs, rs880315 and rs11072518, showed a trend towards association with stroke risk, but did not reach statistical significance.
CONCLUSIONS
Our study suggests that genetic variants in systolic pressure-related genotypes may contribute to the etiology of ischemic stroke.
目的
孤立性收缩期高血压（ISH）是缺血性脑卒中最重要的危险因素。影响高血压的遗传变异也可能是缺血性脑卒中的危险因素。在这里，我们研究了与血压相关的单核苷酸多态性（SNP）如何影响缺血性脑卒中的风险。
患者和方法
我们选择了 300 例缺血性脑卒中患者和 300 例对照。然后，我们对两组中与收缩压相关的三个单核苷酸多态性进行了基因分型。
结果
Logistic 回归分析显示，rs11099098 基因型与 IS 显著降低的风险相关（显性模型：OR = 0.55，95%CI = 0.37-0.82，p = 0.003）。另外两个 SNP，rs880315 和 rs11072518，与卒中风险呈趋势相关，但未达到统计学意义。
结论
我们的研究表明，与收缩压相关的基因型中的遗传变异可能有助于缺血性脑卒中的病因学。
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