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过氧化物酶体增殖物激活受体γ在脑缺血再灌注损伤中的保护作用

The Protective Effects of Peroxisome Proliferator-Activated Receptor Gamma in Cerebral Ischemia-Reperfusion Injury.

作者信息

Ding Yanping, Kang Jie, Liu Shuning, Xu Yuqin, Shao Baoping

机构信息

College of Life Science, Northwest Normal University, Lanzhou, China.

College of Life Science, Lanzhou University, Lanzhou, China.

出版信息

Front Neurol. 2020 Nov 17;11:588516. doi: 10.3389/fneur.2020.588516. eCollection 2020.

Abstract

Cerebral ischemia-reperfusion injury (CI/RI) is a complex pathological process that often occurs secondary to trauma, surgery, and shock. Peroxisome proliferator activated receptor gamma (PPARγ) is a subunit of the PPAR and is a ligand-activated nuclear transcription factor. After being activated by its ligand, PPARγ can combine with specific DNA response elements to regulate the transcription and expression of genes. It has a wide range of biological functions, such as regulating lipid metabolism, improving insulin sensitivity, modulating anti-tumor mechanisms, and inhibiting inflammation. In recent years, some studies have shown that PPARγ exerts a protective effect during CI/RI. This article aims to summarize the research progress of studies that have investigated the protective effects of PPARγ in CI/RI and the cellular and molecular mechanisms through which these effects are modulated, including inhibition of excitatory amino acid toxicity, reduced Ca overload, anti-oxidative stress, anti-inflammation, inhibition of microglial activation, maintain the BBB, promotion of angiogenesis, and neurogenesis and anti-apoptotic processes.

摘要

脑缺血再灌注损伤(CI/RI)是一种复杂的病理过程,常继发于创伤、手术和休克。过氧化物酶体增殖物激活受体γ(PPARγ)是PPAR的一个亚基,是一种配体激活的核转录因子。被其配体激活后,PPARγ可与特定的DNA反应元件结合,调节基因的转录和表达。它具有广泛的生物学功能,如调节脂质代谢、提高胰岛素敏感性、调节抗肿瘤机制和抑制炎症。近年来,一些研究表明PPARγ在CI/RI过程中发挥保护作用。本文旨在总结研究PPARγ在CI/RI中的保护作用及其调节这些作用的细胞和分子机制的研究进展,包括抑制兴奋性氨基酸毒性、减少钙超载、抗氧化应激、抗炎、抑制小胶质细胞活化、维持血脑屏障、促进血管生成、神经发生和抗凋亡过程。

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