Oncology Program, Vall D'Hebron Research Institute, Barcelona, Spain.
Thomas Steitz Laboratory, Department of Molecular Biophysics & Biochemistry, Center for Structural Biology, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut.
Med Res Rev. 2017 Nov;37(6):1275-1298. doi: 10.1002/med.21459. Epub 2017 Jul 6.
Mitochondrial dysfunction (MDF) has been identified as an important factor in various diseases ranging from neurological disorders, to diseases of the cardiovascular system and metabolic syndromes. MDF was also found in cancer as well as in cancer predisposition syndromes with defective DNA damage response (DDR) machinery. Moreover, a recent highlight arises from the detection of MDF in eukaryotic cells upon treatment with antibiotics. In this review, we focus on recent studies of MDF in pathological conditions with a particular emphasis on the effects of various classes of antibiotics on mitochondria. Special attention is given to the role of autophagy/mitophagy in MDF and repurposing antibiotics as anticancer drugs.
线粒体功能障碍（MDF）已被确定为各种疾病的重要因素，这些疾病范围从神经紊乱到心血管系统疾病和代谢综合征。MDF 也存在于癌症以及 DNA 损伤反应（DDR）机制有缺陷的癌症易感性综合征中。此外，最近的一个亮点是在使用抗生素治疗真核细胞时检测到 MDF。在这篇综述中，我们重点关注病理条件下 MDF 的最新研究，特别强调各种类别的抗生素对线粒体的影响。特别关注自噬/线粒体自噬在 MDF 中的作用以及将抗生素重新用作抗癌药物。
