Guangxue Cui, Xiaolei Gao, Xinhua Liang
Dept. of Oral and Maxillofacial Surgery, Affiliated Hospital of Chifeng University, Chifeng 024000, China.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Apr 1;35(2):187-191. doi: 10.7518/hxkq.2017.02.015.
Human papillomavirus (HPV) is a major causative agent of cervical cancers. Over the past several decades, increasing number of studies established strong association of HPV with a subset of head and neck squamous cell carcinomas (HNSCCs). In the present study, we reviewed evidence, including epidemiology, carcinogens, diagnosis, treatment, and prognosis, showing that HPV-positive HNSCCs exhibit a variety of distinct characteristics for understanding tumor biology and improving cancer treatment.
人乳头瘤病毒(HPV)是宫颈癌的主要致病因素。在过去几十年中,越来越多的研究证实HPV与一部分头颈部鳞状细胞癌(HNSCC)存在密切关联。在本研究中,我们回顾了包括流行病学、致癌物、诊断、治疗和预后等方面的证据,这些证据表明HPV阳性的HNSCC表现出多种独特特征,有助于理解肿瘤生物学并改善癌症治疗。