[人乳头瘤病毒阳性头颈部鳞状细胞癌的发病机制、治疗及预后研究进展]
[Research progress in pathogenesis, treatment and prognosis of HPV positive head and neck squamous cell carcinoma].
作者信息
Shui C Y, Li C, Liu W, Cai Y C, Jiang J, Sun R H, Zhou Y Q, Qin G
机构信息
Department of Clinical Medicine of Southwest Medical University, Luzhou 646200, Sichuan Province, China; Department of Head and Neck Surgery, Sichuan Cancer Hospital, Sichuan Institute of Cancer Research, Sichuan Cancer Prevention and Control Center, Department of Head and Neck Surgery, Affiliated Hospital, Medical College, University of Electronic Science and Technology, Chengdu 610041, China.
Department of Head and Neck Surgery, Sichuan Cancer Hospital, Sichuan Institute of Cancer Research, Sichuan Cancer Prevention and Control Center, Department of Head and Neck Surgery, Affiliated Hospital, Medical College, University of Electronic Science and Technology, Chengdu 610041, China.
出版信息
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 May 7;53(5):392-396. doi: 10.3760/cma.j.issn.1673-0860.2018.05.014.
Head and neck squamous cell carcinoma (HNSCC) is the sixth common malignant tumors of whole body with a high incidence, which accounts for 90% of the head and neck malignant tumors. Previous studies have shown the risk factors, such as tobacco and alcohol, are related to the occurrence and development of HNSCC. However, recent studies have shown that the non-tobacco and non-alcohol related HNSCC increased year by year. At the same time, more and more studies have shown that HNSCC is related to the infection with human papilloma virus (HPV), and the occurrence and development of HPV-positive HNSCC has own characteristics in epidemiology, pathogenesis, treatment and prognosis. In this paper the research progress for HPV-positive HNSCC is reviewed.
头颈部鳞状细胞癌（HNSCC）是全身第六大常见恶性肿瘤，发病率高，占头颈部恶性肿瘤的90%。既往研究表明，烟草和酒精等危险因素与HNSCC的发生发展有关。然而，近期研究显示，非烟草和非酒精相关的HNSCC逐年增加。同时，越来越多的研究表明，HNSCC与人乳头瘤病毒（HPV）感染有关，HPV阳性HNSCC的发生发展在流行病学、发病机制、治疗及预后方面具有自身特点。本文就HPV阳性HNSCC的研究进展进行综述。
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