Vergura Michele, Prencipe Michele, Del Giudice Antonio Maria, Grifa Rachele, Miscio Filomena, Pennelli Anna Maria, Popolizio Teresa, Simeone Anna, Ferrara Mariangela, Leone Maurizio, Aucella Filippo
Struttura Complessa di Nefrologia e Dialisi IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italia.
Dipartimento di Diagnostica per Immagini IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italia.
G Ital Nefrol. 2017 Apr;34(2):100-109.
Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiological syndrome, usually reversible, characterized by vasogenic oedema in cerebral posterior regions in patients with autoimmune diseases, nephropathies, hypertensive crisis, eclampsia and exposure to cytotoxic drugs. The main symptoms are: headache, nausea, vomiting, seizures, visual disturbance and altered consciousness. Complications as cerebral hemorrhage and recurrences are rare. We describe a case of a 65 years old woman, affected by chronic kidney disease, recently exacerbated, diabetes and hypertension in treatment, who showed an heterogeneous clinical presentation with vomiting, headache, blurred vision and impaired consciousness during an episode of acute hypertension. After an adjustement of the antihypertensive treatment we observed a regression of symptoms in one week. FLAIR sequences on MRI showed cerebral bilateral vasogenic oedema in posterior regions, typical for PRES. This case was suggestive for PRES and a prompt adjustement of the antihypertensive treatment was critical for clinical recovery. Brain MRI was crucial for diagnosis. It is important for clinicians to recognize PRES as a possible complication of renal disease and hypertensive crisis.
后部可逆性脑病综合征(PRES)是一种临床-放射学综合征,通常具有可逆性,其特征为自身免疫性疾病、肾病、高血压危象、子痫以及接触细胞毒性药物的患者大脑后部区域出现血管源性水肿。主要症状包括:头痛、恶心、呕吐、癫痫发作、视觉障碍和意识改变。脑出血和复发等并发症较为罕见。我们描述了一例65岁女性病例,该患者患有慢性肾脏病,近期病情加重,同时患有糖尿病且正在接受高血压治疗,在一次急性高血压发作期间表现出呕吐、头痛、视力模糊和意识障碍等异质性临床表现。在调整降压治疗后,我们观察到症状在一周内消退。MRI的液体衰减反转恢复(FLAIR)序列显示大脑后部区域双侧血管源性水肿,这是PRES的典型表现。该病例提示为PRES,迅速调整降压治疗对临床恢复至关重要。脑部MRI对诊断至关重要。临床医生认识到PRES是肾病和高血压危象的一种可能并发症很重要。