德国西南部五例由媒介传播的全北区土拉弗朗西斯菌感染病例及基因多样性
Five cases of vector-borne Francisella tularensis holarctica infections in south-western Germany and genetic diversity.
作者信息
Borde Johannes P, Zange Sabine, Antwerpen Markus H, Georgi Enrico, von Buttlar Heiner, Kern Winfried V, Rieg Siegbert
机构信息
Praxis Dr. J. Borde, Gesundheitszentrum Oberkirch, Am Marktplatz 8, 77704 Oberkirch, Germany; Department of Medicine II, Division of Infectious Diseases, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Bundeswehr Institute of Microbiology, Neuherbergstraße 11, 80937 Munich, Germany.
出版信息
Ticks Tick Borne Dis. 2017 Aug;8(5):808-812. doi: 10.1016/j.ttbdis.2017.06.009. Epub 2017 Jul 1.
Tularemia is a rare zoonotic disease in Germany. Francisella tularensis has been isolated previously from ticks in southern Germany underscoring the importance of ticks (Ixodes ricinus) in tularemia transmission, but there have been only few reports from this region with single cases or small case series of tick-borne transmissions of tularemia. We report five cases of non-game animal associated tularemia diagnosed from 2010 to 2016 in southwestern Germany - Baden-Wuerttemberg. Our case series and molecular typing (MLVA) results add published clinical experience to this underdiagnosed disease and consolidate previous findings regarding tick-borne transmission of tularemia and phylogenetic diversity in Germany.
兔热病在德国是一种罕见的人畜共患病。此前在德国南部的蜱虫中分离出了土拉弗朗西斯菌，这突出了蜱虫（蓖麻硬蜱）在兔热病传播中的重要性，但该地区仅有少数关于兔热病蜱传单个病例或小病例系列的报告。我们报告了2010年至2016年在德国西南部巴登 - 符腾堡州诊断出的5例与非猎物动物相关的兔热病病例。我们的病例系列和分子分型（MLVA）结果为这种诊断不足的疾病增添了已发表的临床经验，并巩固了此前关于德国兔热病蜱传和系统发育多样性的研究结果。
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