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兔热病蔓延至西方:奥地利一种新出现感染病的流行病学

Tularemia Goes West: Epidemiology of an Emerging Infection in Austria.

作者信息

Seiwald Stefanie, Simeon Anja, Hofer Erwin, Weiss Günter, Bellmann-Weiler Rosa

机构信息

Department of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Institute for Veterinary Disease Control, Austrian Agency for Health and Food Safety (AGES), 2340 Mödling, Austria.

出版信息

Microorganisms. 2020 Oct 16;8(10):1597. doi: 10.3390/microorganisms8101597.

Abstract

The zoonotic disease tularemia is caused by the Gram-negative bacterium , with the two major subspecies and being responsible for infections in humans and animals. The subspecies is less virulent and prevalent in Europe and Asia. Over the last few centuries, few epidemic outbreaks and low numbers of infections have been registered in the eastern part of Austria, specifically in the provinces of Lower Austria, Burgenland, and Styria. The reported infections were mostly associated with hunting hares and the skinning of carcasses. Within the last decade, ticks have been identified as important vectors in Tyrol and served as first evidence for the spread of to Western Austria. In 2018, the pathogen was detected in hares in the provinces of Tyrol, Vorarlberg, and Salzburg. We presume that is now established in most regions of Austria, and that the investigation of potential host and vector animals should be spotlighted by public institutions. Tularemia in humans presents with various clinical manifestations. As glandular, ulceroglandular, and typhoidal forms occur in Austria, this infectious disease should be considered as a differential diagnosis of unknown fever.

摘要

人畜共患疾病兔热病由革兰氏阴性菌引起,其两个主要亚种分别导致人类和动物感染。亚种在欧洲和亚洲的毒性较低且较为普遍。在过去几个世纪里,奥地利东部,特别是下奥地利州、布尔根兰州和施蒂利亚州,几乎没有大规模疫情爆发,感染病例数量也较少。报告的感染大多与猎杀野兔和剥兔皮有关。在过去十年中,蜱虫已被确定为蒂罗尔州的重要传播媒介,并首次证明已传播到奥地利西部。2018年,在蒂罗尔州、福拉尔贝格州和萨尔茨堡州的野兔中检测到了这种病原体。我们推测现在在奥地利的大多数地区都已发现,公共机构应重点关注对潜在宿主和传播媒介动物的调查。人类兔热病有多种临床表现。由于奥地利出现了腺型、溃疡腺型和伤寒型,这种传染病应被视为不明发热的鉴别诊断疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26dd/7602993/e6de068ae5e1/microorganisms-08-01597-g001.jpg

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