Lin Q, Lin Z-H, Chen J, Lin J-X, Li X, Jiang J-R, Ma X-K, Wu D-H, Chen Z-H, Dong M, Wei L, Wang T-T, Ruan D-Y, Lin Z-X, Wen J-Y, Wu X-Y, Huang M-S
Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, 600, Tianhe Road, 510630 Guangzhou, People's Republic of China.
Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, 600, Tianhe Road, 510630 Guangzhou, People's Republic of China.
Curr Res Transl Med. 2017 Apr-Jun;65(2):83-87. doi: 10.1016/j.retram.2017.06.002. Epub 2017 Jul 3.
This study aimed to assess the prognostic value of the serum albumin to globulin ratio (AGR) in cholangiocarcinoma patients after surgery.
We retrospectively enrolled 123 cholangiocarcinoma patients who underwent surgical treatment between June 2003 and September2014 at the Third Affiliated Hospital of Sun Yat-sen University. Univariate and multivariate analyses using the Cox regression model were performed to determine the prognostic value of AGR.
Univariate analysis suggested that AGR was a predictive factor for (overall survival) OS but not for recurrence free survival (RFS). After adjustment for other risk factors, multivariate analysis showed that AGR remained independently associated with OS. The optimal cut-off point for AGR was determined to be 1.44. Kaplan-Meier curves showed that there was a significantly lower mean survival time in the low AGR group compared to the high AGR group. A low AGR was found to be significantly associated with high alkaline phosphatase, gamma-glutamyl transpeptidase, total bilirubin levels and an advanced American Joint Committee on Cancer TNM stage, but a low hemoglobin level.
In summary, patients with higher AGRs have better outcomes than those with lower AGRs. Preoperative AGR can be a reliable marker for evaluating the prognosis of cholangiocarcinoma patients.
本研究旨在评估血清白蛋白与球蛋白比值（AGR）对胆管癌患者术后的预后价值。
我们回顾性纳入了2003年6月至2014年9月在中山大学附属第三医院接受手术治疗的123例胆管癌患者。采用Cox回归模型进行单因素和多因素分析，以确定AGR的预后价值。
单因素分析表明，AGR是总生存期（OS）的预测因素，但不是无复发生存期（RFS）的预测因素。在对其他危险因素进行校正后，多因素分析显示AGR仍与OS独立相关。AGR的最佳截断点确定为1.44。Kaplan-Meier曲线显示，低AGR组的平均生存时间明显低于高AGR组。发现低AGR与高碱性磷酸酶、γ-谷氨酰转肽酶、总胆红素水平以及美国癌症联合委员会（AJCC）TNM分期晚期显著相关，但与低血红蛋白水平相关。
总之，AGR较高的患者比AGR较低的患者预后更好。术前AGR可作为评估胆管癌患者预后的可靠指标。
