1-（氨甲酰基甲基）-2-芳基-3,1-苯并恶嗪的合成及杀菌活性
Synthesis and Fungicidal Activity of 1-(Carbamoylmethyl)-2-aryl-3,1-benzoxazines.
作者信息
Tang Zi-Long, Wang Lian, Tan Jing-Zhao, Wan Yi-Chao, Jiao Yin-Chun
机构信息
Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, Hunan University of Science and Technology, Xiangtan 411201, China.
School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China.
出版信息
Molecules. 2017 Jul 6;22(7):1103. doi: 10.3390/molecules22071103.
A series of new 1-(carbamoylmethyl)-2-aryl-3,1-benzoxazines were prepared in moderate to good yields by BF₃·OEt₂-catalyzed reactions of aromatic aldehydes with 2-(-substituted carbamoylmethylamino)benzyl alcohols. The structures of the target compounds were confirmed by IR, ¹H-NMR, C-NMR, and elemental analyses. The fungicidal activities of the target compounds against plant fungi were preliminarily evaluated, and some of them exhibited good activity.
通过三氟化硼乙醚催化芳香醛与2-（取代氨基甲酰基甲基氨基）苄醇反应，以中等至良好的产率制备了一系列新型1-（氨基甲酰基甲基）-2-芳基-3,1-苯并恶嗪。通过红外光谱、¹H-NMR、C-NMR和元素分析确定了目标化合物的结构。初步评估了目标化合物对植物真菌的杀菌活性，其中一些表现出良好的活性。
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