School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China.
Molecules. 2012 Jul 6;17(7):8174-85. doi: 10.3390/molecules17078174.
A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, ¹H-NMR, ¹³C-NMR, MS and elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated, and some compounds exhibited good activity against Rhizoctonia solani.
一系列新型 2,3-二取代-3,4-二氢-2H-1,3-苯并恶嗪是通过在 TMSCl 存在下，用 2-(N-取代氨甲基)苯酚与芳香醛的氮杂缩醛化反应以中等至优秀的产率制备的。它们的结构通过 IR、1H-NMR、13C-NMR、MS 和元素分析得到证实。目标化合物的杀菌活性进行了初步评价，一些化合物对茄丝核菌表现出良好的活性。
