产碳青霉烯酶菌株中头孢他啶-阿维巴坦耐药的出现及碳青霉烯类药物敏感性的恢复：一例报告及文献综述
Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Carbapenemase-Producing : A Case Report and Review of Literature.
作者信息
Shields Ryan K, Nguyen M Hong, Press Ellen G, Chen Liang, Kreiswirth Barry N, Clancy Cornelius J
机构信息
Department of Medicine, University of Pittsburgh, Pennsylvania.
XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pennsylvania.
出版信息
Open Forum Infect Dis. 2017 Jul 1;4(3):ofx101. doi: 10.1093/ofid/ofx101. eCollection 2017 Summer.
We used meropenem to successfully treat a patient with bacteremia due to ceftazidime-avibactam-resistant, meropenem- susceptible that carried mutant . Meropenem was bactericidal against ceftazidime-avibactam- resistant isolates in vitro. Nevertheless, the role of carbapenems in treating such infections remains uncertain, because meropenem resistance is selected readily during passage experiments.
我们使用美罗培南成功治疗了一名因对头孢他啶-阿维巴坦耐药但对美罗培南敏感且携带突变体而发生菌血症的患者。美罗培南在体外对头孢他啶-阿维巴坦耐药菌株具有杀菌作用。然而，碳青霉烯类药物在治疗此类感染中的作用仍不确定，因为在传代实验过程中美罗培南耐药性很容易被筛选出来。
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