递质释放机制：电压假说和钙假说。
Mechanism of transmitter release: voltage hypothesis and calcium hypothesis.
作者信息
Zucker R S, Landò L
出版信息
Science. 1986 Feb 7;231(4738):574-9. doi: 10.1126/science.2868525.
PMID:2868525
Abstract
The calcium hypothesis of synaptic transmission has been challenged by experimental results using the crayfish neuromuscular junction that suggest that presynaptic depolarization can trigger transmitter release directly without calcium influx. Results from electrophysiological experiments using the same preparation do not support this voltage hypothesis, but are consistent with the calcium hypothesis. Voltage may modulate, but not elicit, transmitter release.
摘要
使用小龙虾神经肌肉接头的实验结果对突触传递的钙假说提出了挑战，这些结果表明突触前去极化可直接触发递质释放，而无需钙内流。使用相同标本进行的电生理实验结果并不支持这种电压假说，而是与钙假说一致。电压可能调节但不能引发递质释放。
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