使用顺磁氧传感器OxyChip在兔肿瘤临床前模型中测量氧分压（pO）
Measurement of pO in a Pre-clinical Model of Rabbit Tumor Using OxyChip, a Paramagnetic Oxygen Sensor.
作者信息
Hou H, Khan N, Kuppusamy P
机构信息
Department of Radiology, Geisel School of Medicine at Dartmouth College, Rubin 601, 1 Medical Center Drive, Lebanon, NH, 03756, USA.
出版信息
Adv Exp Med Biol. 2017;977:313-318. doi: 10.1007/978-3-319-55231-6_41.
The objective of this work was to establish a novel and robust technology, based on electron paramagnetic resonance (EPR) oximetry, as a practical tool for measurement of tumor oxygen. Previously, we have reported on the development of oxygen-sensing paramagnetic crystals (LiNc-BuO) encapsulated in a biocompatible polymer, called OxyChip. In this report we present our recent data on the use of OxyChip for pO measurements in the tumor of a pre-clinical, large-animal rabbit model. The results establish that OxyChip is capable of noninvasive and repeated measurement of pO in a large animal model.
这项工作的目标是建立一种基于电子顺磁共振（EPR）血氧测定法的新颖且强大的技术，作为测量肿瘤氧含量的实用工具。此前，我们已报道了一种封装在名为OxyChip的生物相容性聚合物中的氧敏感顺磁晶体（LiNc-BuO）的研发情况。在本报告中，我们展示了关于在临床前大型动物兔模型的肿瘤中使用OxyChip进行pO测量的最新数据。结果表明，OxyChip能够在大型动物模型中对pO进行无创且重复的测量。
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