肿瘤的体内氧分压成像：极低频率电子顺磁共振血氧测定法
In Vivo pO2 Imaging of Tumors: Oxymetry with Very Low-Frequency Electron Paramagnetic Resonance.
作者信息
Epel Boris, Halpern Howard J
机构信息
Center for Electron Paramagnetic Resonance Imaging In Vivo Physiology, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois, USA.
Center for Electron Paramagnetic Resonance Imaging In Vivo Physiology, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois, USA.
出版信息
Methods Enzymol. 2015;564:501-27. doi: 10.1016/bs.mie.2015.08.017. Epub 2015 Sep 26.
Abstract
For over a century, it has been known that tumor hypoxia, regions of a tumor with low levels of oxygenation, are important contributors to tumor resistance to radiation therapy and failure of radiation treatment of cancer. Recently, using novel pulse electron paramagnetic resonance (EPR) oxygen imaging, near absolute images of the partial pressure of oxygen (pO2) in tumors of living animals have been obtained. We discuss here the means by which EPR signals can be obtained in living tissues and tumors. We review development of EPR methods to image the pO2 in tumors and the potential for the pO2 image acquisition in human subjects.
摘要
一个多世纪以来，人们已经知道肿瘤缺氧，即肿瘤中氧合水平较低的区域，是肿瘤对放射治疗产生抗性以及癌症放射治疗失败的重要原因。最近，通过使用新型脉冲电子顺磁共振（EPR）氧成像技术，已经获得了活体动物肿瘤中氧分压（pO2）的近乎绝对的图像。我们在此讨论在活体组织和肿瘤中获取EPR信号的方法。我们回顾了用于肿瘤中pO2成像的EPR方法的发展以及在人体受试者中获取pO2图像的潜力。
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