Department of Radiology, Vancouver General Hospital, Vancouver, BC, Canada.
Department of Radiation Oncology, BC Cancer Agency, Vancouver, BC, Canada.
Future Oncol. 2017 Jul;13(16):1437-1448. doi: 10.2217/fon-2017-0061. Epub 2017 Jul 7.
Primary liver cancer, mainly hepatocellular carcinoma, is one of the most common malignancies worldwide. Surgical management, either resection or transplantation, is considered definitive treatment, however, less than 20% of patients are ultimately candidates. Thermal ablation modalities such as radiofrequency ablation and microwave ablation have evolved such that these modalities have been applied with curative intent. Moreover, thermal ablation has demonstrated efficacy in treating early-stage tumors and can be offered as first-line treatment in patients with uncomplicated disease. Attributing to refinements in technology and techniques, recent studies evaluating stereotactic ablative body radiotherapy have shown promising results, while irreversible electroporation, an emerging modality, may further expand the role of ablative therapy in treating potentially resectable hepatocellular carcinoma.
原发性肝癌，主要是肝细胞癌，是全球最常见的恶性肿瘤之一。手术治疗，包括切除术或肝移植，被认为是根治性治疗，但最终只有不到 20%的患者符合条件。射频消融和微波消融等热消融方式已经得到了发展，这些方式已经被用于根治性治疗。此外，热消融在治疗早期肿瘤方面已被证明有效，并且可以作为无并发症疾病患者的一线治疗方法。由于技术和技术的改进，最近评估立体定向消融体放射治疗的研究显示出了有希望的结果，而作为一种新兴方式的不可逆电穿孔术可能会进一步扩大消融治疗在治疗潜在可切除肝细胞癌中的作用。
