骨桥蛋白多态性增加了男性幽门螺杆菌感染患者胃癌前肠化生的易感性。

Osteopontin polymorphism increases gastric precancerous intestinal metaplasia susceptibility in Helicobacter pylori infected male.

机构信息

Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Institute of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

出版信息

Future Oncol. 2017 Jul;13(16):1415-1425. doi: 10.2217/fon-2017-0006. Epub 2017 Jul 7.

DOI:10.2217/fon-2017-0006

PMID:28685609

Abstract

AIM

Whether genetic polymorphisms of osteopontin (OPN) coding gene, SPP1, determine the risk of gastric precancerous intestinal metaplasia (IM) in Helicobacter pylori infected patients.

PATIENTS & METHODS: Helicobacter pylori infected patients (100 with and 210 without IM) were recruited to evaluate the associations of SPP1 promoter polymorphisms with gastric IM and adjusted for age, sex and smoking. Gastric OPN expression and inflammation were evaluated by immunohistochemistry, and haemotoxylin and eosin stain.

RESULTS

Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004). Nearly 87.5% of males with IM carried risky genotype or haplotype. Carriers of the risky genotype or haplotype also had increased gastric OPN expression (p = 0.038) and inflammation (p = 0.007).

CONCLUSION

SPP1 polymorphisms predispose to IM development in H. pylori infected males.

摘要

目的

探讨骨桥蛋白（OPN）编码基因 SPP1 的遗传多态性是否决定了幽门螺杆菌感染患者发生胃癌前肠化生（IM）的风险。

患者与方法

招募了 100 名幽门螺杆菌感染伴 IM 患者和 210 名无 IM 患者，以评估 SPP1 启动子多态性与胃 IM 的相关性，并调整年龄、性别和吸烟因素。通过免疫组织化学和苏木精-伊红染色评估胃 OPN 表达和炎症。

结果

仅在男性中，而不是女性中，rs11730059 的 GG 基因型和 rs6833161-rs2853744-rs11730582 的 C-G-C 单倍型的携带者显著增加了 IM 风险（OR：4.92；95%CI：1.65-14.65；p=0.004）。近 87.5%的男性 IM 患者携带风险基因型或单倍型。携带风险基因型或单倍型的患者胃 OPN 表达（p=0.038）和炎症（p=0.007）也增加。