基因座与膝骨关节炎的风险相关：一项病例对照研究。
gene locus is associated with the risk of knee osteoarthritis: a case-control study.
机构信息
Department of Orthopaedics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, Jiangsu, China.
Department of Operation and Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, Jiangsu, China
出版信息
Biosci Rep. 2019 Feb 27;39(2). doi: 10.1042/BSR20182023. Print 2019 Feb 28.
Abstract
Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). The purpose of this case-control study was to investigate the association between gene rs11730582 polymorphism and knee OA risk in a Chinese population. Genotyping was analyzed using standard PCR and restriction fragment length polymorphism (PCR-RFLP). The present study found that C allele or CC genotype of gene rs11730582 polymorphism was related to decreased risk for knee OA. Furthermore, positive associations were obtained amongst the females, and body mass index (BMI) < 25 kg/m groups. To sum up, the present study reveals that gene rs11730582 polymorphism decreases the risk of knee OA in Chinese Han population.
摘要
研究表明，骨桥蛋白（OPN）与膝骨关节炎（OA）的严重程度和发展有关。本病例对照研究的目的是探讨中国人群中基因 rs11730582 多态性与膝骨关节炎风险的关系。基因分型采用标准 PCR 和限制性片段长度多态性（PCR-RFLP）分析。本研究发现，基因 rs11730582 多态性的 C 等位基因或 CC 基因型与膝骨关节炎的风险降低有关。此外，在女性和 BMI<25kg/m2 组中也得到了阳性关联。总之，本研究表明基因 rs11730582 多态性降低了中国汉族人群膝骨关节炎的发病风险。
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