门诊环境中 HIV 感染者的食物摄入与达芦那韦血浆浓度。
Food intake and darunavir plasma concentrations in people living with HIV in an outpatient setting.
机构信息
University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands.
University of Groningen, University Medical Center Groningen, Department of Dietetics, Groningen, The Netherlands.
出版信息
Br J Clin Pharmacol. 2017 Oct;83(10):2325-2329. doi: 10.1111/bcp.13366. Epub 2017 Aug 1.
AIMS
Patients receiving darunavir are advised to take it concomitantly with food. The objectives of the present cross-sectional study were to evaluate the actual concomitant food intake of patients visiting an HIV outpatient clinic.
METHODS
Sixty participants treated with darunavir/ritonavir once daily were subjected to a food recall questionnaire concerning their last concomitant food intake with darunavir. Darunavir trough concentrations were calculated.
RESULTS
The median food intake was 507 (0-2707) kcal; protein intake, 20 (0-221)g; carbohydrate intake, 62 (0-267)g; fat intake: 14 (0-143)g; and dietary fibre: 4 (0-30)g. Twenty-five patients (42%) ingested their drug with between-meal snacks. No relationship was found between food intake and trough concentrations.
CONCLUSIONS
Clear advice on the optimal caloric intake is needed, to avoid high caloric intake in patients who already have an increased risk of cardiovascular disease due to their HIV infection.
目的
接受达芦那韦治疗的患者被建议同时进食。本横断面研究的目的是评估在 HIV 门诊就诊的患者实际同时进食达芦那韦的情况。
方法
对 60 名每日接受一次达芦那韦/利托那韦治疗的患者进行了有关他们最近同时进食达芦那韦的食物回忆问卷调查。计算达芦那韦谷浓度。
结果
中位食物摄入量为 507（0-2707）千卡；蛋白质摄入量为 20（0-221）g；碳水化合物摄入量为 62（0-267）g；脂肪摄入量为 14（0-143）g；膳食纤维摄入量为 4（0-30）g。25 名患者（42%）在用餐之间吃零食时服药。食物摄入量与谷浓度之间没有相关性。
结论
需要就最佳热量摄入提供明确建议，以避免因 HIV 感染而使心血管疾病风险增加的患者摄入高热量。
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